'Normal' TSH Levels Increase Risks of Fatal Heart Disease

There is still so much we don't understand about our thyroid and how it's related to menopause. The symptoms are so similar so in this forum we can talk and learn about each other's experiences and research.

'Normal' TSH Levels Increase Risks of Fatal Heart Disease

Postby Seventeen_At_Heart » Fri May 02, 2008 3:34 am

from
http://thyroid.about.com/od/heartdiseas ... e.htm?nl=1

Research has shown that overt hypothyroidism and hyperthyroidism are linked to an increased risk of coronary heart disease, but a 2008 study out of Norway looked at the impact of thyroid levels considered well within the normal reference range on the risk of fatal heart disease.
More than 25,000 people were included in the study. The study participants were grouped into five different categories according to their Thyroid Stimulating Hormone (TSH) level:

TSH: less than 0.50
TSH: 0.50-1.4
TSH: 1.5-2.4
TSH 2.5-3.5
TSH: 3.6 and higher

For the purposes of the study, the TSH reference range was defined as 0.50 to 3.5 mIU/L. (Note: The reference range for laboratories in the United States is typically much wider and runs from approximately 0.50 to 5.5mIU/L. Since 2002, however, some endocrinologists have recommended that the level be narrowed to a range of 0.30 to 3.0.)
During the more than eight-year follow-up of the study, 228 women (1.3%) and 182 men (2.3%) died of coronary heart disease. Of these, 192 women and 164 men had TSH levels within the reference range the researchers used for this study.

The 0.50 to 1.4 TSH range was used as the baseline control group, and as TSH levels rose into the ranges higher than 1.4, the "hazard ratio," which in this case estimated the relative risk of fatal coronary heart disease, also rose in women. (While there was some rise for men, it was not enough to be considered statistically significant.)

The analysis was repeated in another follow-up two years later, and the findings were again consistent with the initial research.

Ultimately, the researchers concluded that there is a clear connection between even low -- but clinically normal -- thyroid function in women and fatal coronary heart disease.

The researchers reported that, to their knowledge, there have not been any clinical trials to determine if thyroid hormone replacement might help protect against coronary heart disease. They did note, however, that other research has shown that thyroid hormone replacement treatment may improve cholesterol levels, improve endothelial function (a measure of vascular disease) and reduce other signs of atherosclerosis.


What This Means for the Public?
Certainly, these findings make it especially important that further gender-specific studies be conducted, with a goal of determining if thyroid hormone replacement for people with TSH levels above 1.4 will reduce the risk of fatal coronary heart disease.
And given that we already know that thyroid hormone replacement can improve various markers for heart disease, there is increasing evidence that the endocrinology and laboratory community need to finally come to some agreement over adopting the recommended narrower reference range.

Source:

Åsvold, Bjørn MD; et. al. "Thyrotropin Levels and Risk of Fatal Coronary Heart Disease: The HUNT Study," Arch Intern Med. 2008;168(8):855-860. Online

Updated: April 30, 2008 More on the TSH Reference Range
Does Your Doctor Know About the New TSH Lab Standards?
The TSH Reference Range Wars
Born 1959
Hashimoto's hypothyroid finally diagnosed 1991 when 30, (after first child).
In pre-menopause. Trying natural progesterone cream.
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Re: 'Normal' TSH Levels Increase Risks of Fatal Heart Disease

Postby minniepauz » Fri May 02, 2008 3:48 pm

Thanks for posting this....very informative. Plus it triggered some thyroid sponsors!
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Re: 'Normal' TSH Levels Increase Risks of Fatal Heart Disease

Postby Seventeen_At_Heart » Fri May 02, 2008 9:19 pm

minniepauz wrote:Plus it triggered some thyroid sponsors!
yay!!!
Born 1959
Hashimoto's hypothyroid finally diagnosed 1991 when 30, (after first child).
In pre-menopause. Trying natural progesterone cream.
User avatar
Seventeen_At_Heart
One HOT Woman!
 
Posts: 383
Joined: Thu Jun 07, 2007 9:57 am
Location: U.K.

Re: 'Normal' TSH Levels Increase Risks of Fatal Heart Disease

Postby minniepauz » Mon May 05, 2008 10:08 am

Seventeen_At_Heart wrote:
minniepauz wrote:Plus it triggered some thyroid sponsors!
yay!!!


Check them out and let me know if there's any good information, ok?
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Re: 'Normal' TSH Levels Increase Risks of Fatal Heart Disease

Postby Seventeen_At_Heart » Sat May 10, 2008 7:00 pm

the first one wants personal information and e-mail address before 'analysing'
it does stress the need to possibly see doctor though...

the 2nd is selling 'supplements' which I think some say aren't helpful...maybe Dr. Judy might know about that.
Born 1959
Hashimoto's hypothyroid finally diagnosed 1991 when 30, (after first child).
In pre-menopause. Trying natural progesterone cream.
User avatar
Seventeen_At_Heart
One HOT Woman!
 
Posts: 383
Joined: Thu Jun 07, 2007 9:57 am
Location: U.K.

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