EstroSense, indole-3-carbinol, and turmeric

For those of you who are just beginning this wonderful process, here we can narrow down the symptoms and ask questions like "am I starting perimenopause?"

EstroSense, indole-3-carbinol, and turmeric

Postby pollywog » Fri Sep 30, 2005 6:48 pm

I was wondering if anyone has tried EstroSense and how it worked for you.
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Postby drjudy » Sat Oct 01, 2005 11:18 am

Dear Pw,

I'd not heard of this product, so I looked up the ingredients:

Calcium d-Glucarate 75 mg
Indole-3-Carbinol 75 mg
Broccoli (Brassica oleracea), powdered (floret & stalk) Sulforaphane (0.1%) 100 mg
Sulforaphane (0.1%) 0.1 mg
Green Tea (Camellia sinensis), powdered extract (leaf) 50 mg
Polyphenols (60%) 30 mg
Turmeric (Curcuma longa), powdered (root) 25 mg
Curcumin (95%) 23.8 mg
Milk Thistle (Silybum marianum), powdered extract (fruit) 25 mg
Silymarin (80%) 20 mg
Rosemary (Rosmarinus officinalis), powdered extract (leaf) 12.5 mg
Carnosic acid (6%) 0.75 mg
Lycopene 2.5 mg

$19 for 60 capsules.

There are certainly some healthy components to this blend, In particular, Indole-3-Carbinol, extracted from cabbage, changes the way estrogen is metabolized to make it safer; this is probably a good strategy for women using estrogen or in the high estrogen state of early perimenopause. I will include an article I wrote on this subject in another post.

Turmeric/curcumin is a good antioxidant, and may be useful for preserving brain cells against the ravages of Alzheimer's disease. Green tea and polyphenols are also good anti-oxidants. Lycopene has some potent anti-cancer properties. Milk thistle is good for your liver, and rosemary good for your hair.

What I always wonder about with these propietary products is whether the quantities of included ingredients is too small to do much good and to justify the price. For instance, I take turmeric 400 mg and lycopene 10 mg daily, compared with the 25 mg and 2.5 mg contained in this product. Estrosense provides much less, but who knows how much lycopene or turmeric we really need? The recommended daily dose of indole 3 carbinol for cancer prevention is 400 mg compared with 75 in Estrosense.

I don't know how to advise you on this one; I'd certainly be interested in how you feel on it if you choose to take it.

Best wishes,
Judy
Last edited by drjudy on Sat Oct 01, 2005 11:24 am, edited 1 time in total.
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indole 3 carbinol

Postby drjudy » Sat Oct 01, 2005 11:23 am

Of Cabbages and Cancer

The reasons to substitute coleslaw for french fries continue to pile up. A recent small study suggests that cabbage could someday be the side dish of choice for women with abnormal pap smears.

This investigation found that a derivative of cabbage may reverse cervical dysplasia, a precancerous condition sometimes found on routine pap screening. Half of the women with dysplastic smears who were given supplements of indole-3-carbinol (I3C), a compound found in cruciferous vegetables such as cabbage and broccoli, had significant improvement in their follow-up tests. Some even completely reverted to normal! The dose of I3C was equivalent to 1/3 of a head of cabbage daily.

I3C changes the way the body metabolizes or breaksdown estrogen. Instead of producing a biologically active molecule that causes cells to grow and divide just like estrogen does, this chemical pathway produces a much weaker hormone for safe elimination from the body. For this reason, I3C is used by weight-lifters to block the feminizing side effects of muscle-building steroids which at times are changed to estrogenic hormones by enzymes in body fat and muscle tissue.

Exciting research indicates that this I3C induced change in estrogen metabolism may be helpful in breast cancer prevention. These studies have shown that women with breast cancer have higher levels of the more active estrogen by-product than women with no cancer. This metabolic pathway is linked to tumor growth because the more active estrogenic compound causes cancer cells to proliferate.

I3C may also be useful in preventing bladder cancer. A recent study of 48.000 men found that those who ate five or more servings a week of cabbage or broccoli were less than half as likely to develop such tumors compared with those who could only face the vegetables once a week. By the way, this study also showed that high fluid intake (eight 8 oz. glasses of water daily) was another potent way to prevent bladder cancer.

I3C is relatively expensive, costing around $20 per month at the recommended dose of 400 mg. daily. Cabbage is readily available and cheap, of course, but causes major intestinal gas in some people. In addition, compounds in cabbage called thiocyanates can cause a goiter, an inactive, enlarged thyroid. The proportional amount of indole-3-carbinol taken as a supplement may not only provide as much cancer protection, but would be easier and safer to take.
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Spice curries favor with aging brain

Postby drjudy » Sat Oct 01, 2005 11:26 am

My turmeric has arrived. No ethnic cooking with these 600 capsules of East Indian spice, however, because they're brain food for me. Every so often I come across research so compelling that I shut down the word processor and search the web for the best price on a priceless new product. And three hundred days worth of turmeric for $21.50 at http://www.puritan.com seems like a bargain. Here's why.

Alzheimer's disease causes the accumulation of an abnormal protein called beta amyloid (Abeta) in the brain. Great glumps of Abeta destroy brain cells, perhaps by setting off an inflammatory process in much the same way that cholesterol deposits lead to the destruction of blood vessel walls. Anti-amyloid agents theoretically could prevent this degenerative process.

Enter curcumin or turmeric, the yellow curry pigment which is already known to possess antioxidant and anti-inflammatory properties. Scientists working on mouse brains (both inside and outside the mouse) found that curcumin was a potent inhibitor of Abeta aggregation. In other words, a dash of spice on a mucked-up mouse brain prevented little Abeta clumps from growing into big nasty plaques. Furthermore, Tg2576 mice--bred to be particularly susceptible to senility--with advanced amyloid guck in their brains actually reversed their Abeta plaques when Indian curry replaced their standard American chow.

The authors of this UCLA study published a few months ago in the Journal of Biological Chemistry concluded: "These data suggest that low dose curcumin effectively disaggregates Abeta... supporting the rationale for curcumin use in clinical trials preventing or treating AD." They are currently undertaking just that to see if curcumin can improve mental status in patients already affected by Alzheimer's disease.
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Postby pollywog » Sat Oct 01, 2005 8:33 pm

Thank you,drjudy,for your reply.
I am thinking of trying it ,however I am concerned about drug interactions.I have lupus along with schrogens.I am taking plaquinal and arthrotec and have for about 10 years.
I have to find something that will work with those drugs.
Any added weight increases my pain level,and the flashes are becoming unbearable.I think they will be the straw that broke the camels back.So ,I am hoping to find something that will help me make it thru.
I am very thankful to have found this site.It is comforting to know I am not alone.
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Postby drjudy » Wed Oct 05, 2005 5:43 pm

Do your doctors feel that you are not a candidate for estrogen support during this difficult transition?

I don't think any components of Estrosense would interfere with your medications.

Judy
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Postby pollywog » Wed Oct 05, 2005 6:45 pm

There is a history of breast cancer in my family (my mom,my aunt)so my gp doesn't want to take any chances with hormone replacement.My specialist is concerned because I am a smoker(for now,I have selected a quit date)So here I suffer.

Thank you for your replies.I feel you are the only one who is answering honestly.My GP won't discuss any natural products. :roll: I am sure he has his reasons but I don't know what they are.

Again thanks so much,
PW
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Postby minniepauz » Wed Oct 05, 2005 7:36 pm

PW, congratulations on choosing a start date to quit smoking! If you need any encouragement or tips, let me know....I quit 7 months ago after smoking for 43 years.
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Postby pollywog » Thu Oct 06, 2005 3:55 pm

Thank you,Dee.
I will need all the tips I can get.I have been a smoker for as long as I can remember.I know this will be a very tough battle,but i do so want to win.
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Postby minniepauz » Thu Oct 06, 2005 5:10 pm

I can only tell you what worked for me and it was virtually my first effort to quit. I'm still surprised that I'm finally a non-smoker. Thought I'd never quit. Sometimes I think I "miss" it, but because I've finally realized that it's mind over matter, I can very quickly overcome those thoughts. I think I wrote it all out in the "Can you quit" section of this forum, so I'll have to go look over there. It would be a good place for you to start and there's some excellent links to follow. You've got to do everything you can to stop lying to yourself. For instance: "I like smoking", "I don't want to quit", I'm not hurting anyone else but myself", my health problems are not because of smoking, nobody in my family has ever died from smoking, even the smokers.....smoking relaxes me, I CAN'T stop.....if you can turn every one of those statements around to a truth, that's a good start. Then look at pictures of diseased lungs, look up emphysema and cancer and visualize if you actually had to have oxygen all the time or lost your hair from chemo. Then imagine your kids having to take care of you.....on and on. If you can get to the point where you cannot find one logical reason to continue smoking, you're almost there....it only takes 72 hours to get the nicotine out of your body and then there's no longer a physical craving....that shocked me!! That's when I realized it was the HABIT itself that was hanging on to me. Mind over matter...when you think "I want a cigarette", you just say something like "it's ridiculous to "want" that smoke and tar and chemicals in my body" or something like that until you realize YOU have control over it, not the other way around. :)
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Postby pollywog » Fri Oct 07, 2005 3:37 pm

Congratulations to you.I can't wait to call myself a non-smoker.

If you don't mind I may call on you next month for support.I will try all your tips.

Thank you not only for this,but for this web site,it truly is a lifesaver.

PW
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Re: turmeric benefits

Postby turmeric » Tue Aug 25, 2009 10:53 am

drjudy wrote:What I always wonder about with these propietary products is whether the quantities of included ingredients is too small to do much good and to justify the price. For instance, I take turmeric 400 mg and lycopene 10 mg daily, compared with the 25 mg and 2.5 mg contained in this product. Estrosense provides much less, but who knows how much lycopene or turmeric we really need? The recommended daily dose of indole 3 carbinol for cancer prevention is 400 mg compared with 75 in Estrosense.

Hey, are you still taking turmeric? What are the supposed turmeric benefits?
Turmeric benefits resource, including particular turmeric health benefits.
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